Abstract #0148

Inter-Regional BOLD Latency after Vascular Reactivity Calibration is Correlated to Reaction Time

Yi-Tien Li^1,2, Pu-Yeh Wu¹, Jacky Tai-Yu Lu³, Ying-Hua Chu¹, Yi-Cheng Hsu¹, and Fa-Hsuan Lin^1,4

¹Institute of Biomedical Imaging, National Taiwan University, Taipei, Taiwan, ²Department of Medical Imaging, Taipei Medical University-Shuang Ho Hospital, New Taipei, Taiwan, ³Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ⁴Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland

Inter-regional BOLD latency between visual and sensimotor cortices were first monitored with fast fMRI (TR=0.1 s) and then calibrated for vascular reactivity using a breath-holding task. Significant delayed response (left: t=4.0, p=0.0019; right: t=6.0, p<0.0001) in the sensorimotor cortex was observed than the visual cortex was detected after removing the vascular confound. Significant correlation between reaction time (428 ± 41ms) and the inter-regional BOLD timing difference (432 ± 149ms) was found within and across subjects.

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