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Abstract #0149

Global responses to microstimulation at 7T and comparison with vibrotactile stimulation

Ayan Sengupta1, Rochelle Ackerley2, Roger Watkins2, Rosa Sanchez Panchuelo1, Paul Glover1, Johan Wessberg2, and Susan Francis1

1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2Department of Physiology, University of Gothenburg, Gothenburg, Sweden

Single unit intra-neural microstimulation (INMS) allows the precise delivery of low-current electrical pulses into human peripheral nerves to stimulate individual afferent nerve fibres. We compare the global pattern of positive and negative BOLD response to INMS with that of perceptually matched vibrotactile stimulation of the skin. INMS and vibrotactile stimulation result in a similar pattern of positive BOLD response, but distinct differences in negative BOLD signals. INMS results in strong negative BOLD response of the DMN, whilst vibrotactile stimulation results in strong ipsilateral negative BOLD response likely to represent active inhibition which is not seen for INMS.

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