The hippocampal formation consists of distinct subfields, which contribute to different aspects of memory function, and exhibit different brain network topologies. However, the brain-wide resting-state functional connectivity of hippocampal subfields in human remains poorly understood mainly due to technical limitations. Previous efforts to identify hippocampal subfield functional networks compromised either spatial resolution, spatial coverage or temporal resolution. We have developed a new approach, named Partition-encoded Simultaneous Multi-slab (PRISM), capable of acquiring ultrahigh isotropic resolution images while maintaining the acceleration capability. Our results of resting-state functional connectivity at 7T reveal distinct brain-wide functional networks associated with different hippocampal subfields.
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