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Abstract #0151

High-frequency BOLD responses in human thalamus detected through fast fMRI at 7 Tesla

Laura D Lewis1,2, Kawin Setsompop1,3, Bruce Rosen1,4, and Jonathan R Polimeni1,4

1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 2Society of Fellows, Harvard University, Cambridge, MA, United States, 3Radiology, Harvard Medical School, boston, MA, United States, 4Radiology, Harvard Medical School, Boston, MA, United States

No current technique can noninvasively localize neural activity in human subcortical structures at subsecond temporal resolution. Recent studies have demonstrated that fast (>0.2 Hz) fMRI responses can be detected in human cortex. We aimed to test whether fast fMRI signals can also be detected in the thalamus. We presented oscillating visual stimuli in order to induce oscillatory neural activity in visual thalamus, and observed large-amplitude fMRI oscillations at 0.5 Hz. We conclude that high-frequency fMRI responses can be detected in thalamus, suggesting fast fMRI has the potential to be used for whole-brain imaging.

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