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Abstract #0192

Microscopic susceptibility anisotropy imaging: A clinically viable gradient-echo MRI technique

Enrico Kaden1, Umesh Rudrapatna2, Irina Y. Barskaya3, Mark D. Does3, Derek K. Jones2, and Daniel C. Alexander1

1Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 2Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom, 3Institute of Imaging Science, Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

The orientation dependence of the gradient-echo MR signal in brain white matter conflates two principal effects, (i) the susceptibility properties of tissue microenvironments, especially the myelin microstructure, and (ii) the axon orientation distribution with respect to the external magnetic field. This work introduces a clinically feasible MRI method based on gradient-echo and diffusion measurements, which we refer to as microscopic susceptibility anisotropy imaging, that disentangles both effects, hence enabling us to estimate microscopic susceptibility anisotropy unconfounded by fibre crossings and orientation dispersion as well as magnetic field direction.

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