Abstract #0205

Local associations between intervertebral disc T1rho/T2, muscle health, physical activity, and clinical disability using voxel-based relaxometry

Claudia Iriondo¹, Valentina Pedoia², Jason Talbott², William Dillon², and Sharmila Majumdar²

¹UCSF/UC Berkeley Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA, United States, ²Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

Region of interest based analysis of intervertebral disc composition in low back pain populations is (1) time-consuming and (2) limited in reproducibility, even more so in patients with advanced degeneration. This study applies voxel-based relaxometry (VBR) to investigate the spatial distributions of T_1ρ and T₂ in lumbar intervertebral discs, and their association to patient reported outcomes and spinal muscle health. Our results demonstrate the potential to use VBR as a tool to more effectively measure biochemical differences in the intervertebral discs across low back pain subgroups and monitor changes over time.

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