Abstract #0206

Quantitative MRI in early intervertebral disc degeneration: T1rho correlates better than T2 and ADC with biomechanics and matrix content

Cornelis Paul¹, Theodoor Smit¹, Magda de Graaf², Roderick Holewijn², Arno Bischop², Peter van de Ven³, Margriet Mullender⁴, Marco Helder⁵, and Gustav Strijkers⁶

¹Orthopedic Surgery, Academic Medical Center, Amsterdam, Netherlands, ²Orthopedic Surgery, VU University Medical Center, Amsterdam, Netherlands, ³Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands, ⁴Plastic, Reconstructive and Hand Surgery, VU University Medical Center, Amsterdam, Netherlands, ⁵Oral and Maxillofacial Surgery, VU University Medical Center, Amsterdam, Netherlands, ⁶Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands

We correlated quantitative T2, T1rho and Apparent Diffusion Coefficient (ADC) values to disc mechanical behavior and gold standard early DDD markers in a graded degenerated lumbar IVD caprine model to assess their potential for early DDD detection. T1rho nucleus values correlate better than T2 and ADC with biomechanical, histological, and GAG changes.

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