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Abstract #0224

Impaired modulation of hippocampal glutamate during memory consolidation in schizophrenia: Evidence from ¹H fMRS

Jeffrey A. Stanley1, Patricia Thomas1, Dalal Khatib1, Asadur Chowdury1, Usha Rajan1, Luay Haddad1, Amirsadri Alireza1, and Vaibhav A. Diwadkar1

1Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States

Schizophrenia is one of the most debilitating, life-long mental illnesses where treatment has a limited impact in restoring real-life functions such as deficits in learning and memory. The hippocampus is particularly rich in glutamatergic neurons and altered neuroplasticity related to glutamate has been proposed as a critical mechanism mediating learning and memory in schizophrenia. Understanding glutamate-related dysfunction in schizophrenia may therefore, elucidate mechanisms underlying the illness as well as help tailor intervention strategies. Here we provide the first ever evidence of a dysfunctional modulation of hippocampal glutamate during memory encoding in schizophrenia using ¹H fMRS.

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