Schizophrenia is one of the most debilitating, life-long mental illnesses where treatment has a limited impact in restoring real-life functions such as deficits in learning and memory. The hippocampus is particularly rich in glutamatergic neurons and altered neuroplasticity related to glutamate has been proposed as a critical mechanism mediating learning and memory in schizophrenia. Understanding glutamate-related dysfunction in schizophrenia may therefore, elucidate mechanisms underlying the illness as well as help tailor intervention strategies. Here we provide the first ever evidence of a dysfunctional modulation of hippocampal glutamate during memory encoding in schizophrenia using ¹H fMRS.
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