Abstract #0225

N-acetyl-cysteine supplementation improves functional connectivity in the cingulate cortex in early psychosis

Emeline Mullier¹, Timo Roine¹, Alessandra Griffa², Philipp Baumann³, Philippe Conus⁴, Kim Q. Do⁴, and Patric Hagmann¹

¹Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ²Dutch connectome lab, University Medical Center (UMC), Utrecht, Netherlands, ³Service of General Psychiatry and Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ⁴Department of psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland

Schizophrenia implies different alterations in prefrontal cortex and in particular, a disrupted connectivity in this brain area and a redox dysregulation. In a previous analysis, glutathione levels (main antioxidant and redox regulator) correlated with functional connectivity within the cingulate cortex. In this study, we investigate the effect of N-acetyl-cysteine (NAC) (precursor of glutathione) supplementation on functional connectivity in early psychosis patients. The results show an increased functional connectivity strength and betweenness centrality in these regions, suggesting that cingulate cortex functional connectivity could be a biomarker for NAC treatment efficacy

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