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Abstract #0225

N-acetyl-cysteine supplementation improves functional connectivity in the cingulate cortex in early psychosis

Emeline Mullier1, Timo Roine1, Alessandra Griffa2, Philipp Baumann3, Philippe Conus4, Kim Q. Do4, and Patric Hagmann1

1Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 2Dutch connectome lab, University Medical Center (UMC), Utrecht, Netherlands, 3Service of General Psychiatry and Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 4Department of psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland

Schizophrenia implies different alterations in prefrontal cortex and in particular, a disrupted connectivity in this brain area and a redox dysregulation. In a previous analysis, glutathione levels (main antioxidant and redox regulator) correlated with functional connectivity within the cingulate cortex. In this study, we investigate the effect of N-acetyl-cysteine (NAC) (precursor of glutathione) supplementation on functional connectivity in early psychosis patients. The results show an increased functional connectivity strength and betweenness centrality in these regions, suggesting that cingulate cortex functional connectivity could be a biomarker for NAC treatment efficacy

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