In 27 clinical patients, we performed multi-parametric hepatic MRI, including proton density fat fraction with R2* correction, MR Elastography (MRE), and T1 mapping to characterize nonalcoholic steatohepatitis (NASH). Fat fraction and multiple MRE-assessed mechanical parameters successfully diagnosed NASH (p<0.05 for all). Diagnostic abilities of all parameters were evaluated based on steatosis, inflammation and ballooning scores respectively. Spearman correlations were used to analyze the correlations between imaging parameters. We found that T1 relaxation time had a significantly positive correlation (ρ=0.72, p=0.0005) with fat fraction. In summary, multi-parametric MRI is a potential imaging surrogate for diagnosing NASH.
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