Abstract #0237

Clinical Assessment of Nonalcoholic Steatohepatitis (NASH) with Multi-parametric MRI

Jiahui Li¹, Alina Allen², Yi Sui¹, Dan Rettmann ³, Ann Shimakawa⁴, Glenn Slavin⁵, Kevin J. Glaser¹, Sudhakar K. Venkatesh¹, Taofic Mounajjed⁶, Vijay Shah⁷, Richard L. Ehman¹, and Meng Yin¹

¹Radiology, Mayo Clinic, Rochester, MN, United States, ²Gastroenterology, Mayo Clinic, Rochester, MN, United States, ³GE Healthcare, Waukesha, WI, United States, ⁴GE Healthcare, Menlo Park, CA, United States, ⁵GE Healthcare, Silver Spring, MD, United States, ⁶Anatomic Pathology, Mayo Clinic, Rochester, MN, United States, ⁷Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States

In 27 clinical patients, we performed multi-parametric hepatic MRI, including proton density fat fraction with R2* correction, MR Elastography (MRE), and T1 mapping to characterize nonalcoholic steatohepatitis (NASH). Fat fraction and multiple MRE-assessed mechanical parameters successfully diagnosed NASH (p<0.05 for all). Diagnostic abilities of all parameters were evaluated based on steatosis, inflammation and ballooning scores respectively. Spearman correlations were used to analyze the correlations between imaging parameters. We found that T1 relaxation time had a significantly positive correlation (ρ=0.72, p=0.0005) with fat fraction. In summary, multi-parametric MRI is a potential imaging surrogate for diagnosing NASH.

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