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Abstract #0237

Clinical Assessment of Nonalcoholic Steatohepatitis (NASH) with Multi-parametric MRI

Jiahui Li1, Alina Allen2, Yi Sui1, Dan Rettmann 3, Ann Shimakawa4, Glenn Slavin5, Kevin J. Glaser1, Sudhakar K. Venkatesh1, Taofic Mounajjed6, Vijay Shah7, Richard L. Ehman1, and Meng Yin1

1Radiology, Mayo Clinic, Rochester, MN, United States, 2Gastroenterology, Mayo Clinic, Rochester, MN, United States, 3GE Healthcare, Waukesha, WI, United States, 4GE Healthcare, Menlo Park, CA, United States, 5GE Healthcare, Silver Spring, MD, United States, 6Anatomic Pathology, Mayo Clinic, Rochester, MN, United States, 7Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States

In 27 clinical patients, we performed multi-parametric hepatic MRI, including proton density fat fraction with R2* correction, MR Elastography (MRE), and T1 mapping to characterize nonalcoholic steatohepatitis (NASH). Fat fraction and multiple MRE-assessed mechanical parameters successfully diagnosed NASH (p<0.05 for all). Diagnostic abilities of all parameters were evaluated based on steatosis, inflammation and ballooning scores respectively. Spearman correlations were used to analyze the correlations between imaging parameters. We found that T1 relaxation time had a significantly positive correlation (ρ=0.72, p=0.0005) with fat fraction. In summary, multi-parametric MRI is a potential imaging surrogate for diagnosing NASH.

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