Abstract #0238

Implementation of T1 Mapping in Routine Clinical MR Liver Exam For The Detection of Hepatic Fibrosis and Portal Hypertension in Hepatitis C Patients

Ahmed Hamimi¹, Ronald Ouwerkerk¹, Theo Heller², Elliot Levy³, Jatin Raj Matta¹, Khaled Abd-elmoniem¹, and Ahmed M Gharib¹

¹Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, United States, ²Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, United States, ³Interventional Radiology, Clinical Center, NIH, Bethesda, MD, United States

Application of two short single breath hold T1 mapping shMOLLI technique (before and after Gadolinium injection) to a routine clinical MRI liver exam can detect both severe fibrosis and portal hypertension in Hepatitis C. The technique was prospectively validated in 29 patients with reference standard clinical methods including liver biopsy and direct portal venous pressure measurements. Utilizing this method would allow for a comprehensive anatomic and functional MRI study in a single session without substantial prolongation of scan time, thereby, allow non-invasive monitoring of therapy and/or progression of disease.

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