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Abstract #0261

Non-Invasive Determination of Sodium Pump Activity In Vivo with DWI

Charles S. Springer1, Gregory J. Wilson2, Brendan Moloney1, Thomas M. Barbara1, Xin Li1, William D. Rooney1, and Jeffrey H. Maki3

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Radiology, University of Washington, Seattle, WA, United States, 3Radiology, University of Colorado Denver, Aurora, CO, United States

Using a very simple model, Monte Carlo random walk simulated DWI b-space decays exhibit sensitivity to parameters measuring membrane Na+,K+-ATPase activity, cell density, and voxel average cell volume. Furthermore, the simulation matching the literature experimental in vivo human cerebral cortex b‑space decay has model parameters in near absolute agreement with the most pertinent literature values. The model parameters are: kio = 2 s-1, ρ = 80,400 cells/μL, and V = 9.2 pL. In addition, the ADC of this simulation agrees with published results.

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