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Abstract #0272

In vivo Imaging of Hyperpolarized Silicon-29 Nanoparticles

Grzegorz Kwiatkowski1, Jonas Steinhauser1, Patrick Wespi1, Matthias Ernst2, and Sebastian Kozerke1

1Institute for Biomedical Engineering, ETH & University of Zurich, Zurich, Switzerland, 2Labolatory of Physical Chemistry, ETH Zurich, Zurich, Switzerland

Hyperpolarized silicon particles exhibit very long T1 relaxation at room temperature, making them favourable as novel imaging MR probes. It has recently been shown that silicon particles in the nanometer size range can be efficiently polarized and image even after 4 hours upon transfer of the sample to the imaging system.

The objective of the present work was to demonstrate the imaging capability of surface functionalized hyperpolarized nanometer size silicon particles in an experimental in-vivo setting.

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