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Abstract #0273

An in vivo metabolic imaging study of myopathy in transgenic mice using C-13 hyperpolarized pyruvate generated by ParaHydrogen

Francesca Reineri1, Eleonora Cavallari1, Carla Carrera1, and Silvio Aime1

1Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy

Hyperpolarized [1-13C]pyruvate has been widely exploited for the in vivo investigation of metabolic processes under normal and diseased conditions. The possibility to obtain it using the cost effective and fast PHIP (ParaHydrogen Induced Polarization) method would allow a widespread application of this powerful diagnostic tool to pre-clinical research and would pave the way to future clinical translation. Here we show the first in vivo studies carried out on genetically modified mice using [1-13C]pyruvate obtained by means of the PHIP-SAH (PHIP-Side Arm Hydrogenation) method. The results obtained from PHIP-SAH hyperpolarized pyruvate are consistent with the pathologic state of the heart tissue.

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