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Abstract #0274

Hyperpolarized sodium [1-13C]glycerate as a probe for assessing glycolysis in vivo

Jae Mo Park1,2,3, Marvin Wu4, Thomas Hever1, Xiaodong Wen1, Daniel M Spielman5, and Kelvin Billingsley6

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Electrical and Computer Engineering, University of Texas at Dallas, Richardson, TX, United States, 4Chemistry and Biochemistry, San Francisco State University, San Francisco, CA, United States, 5Stanford University, Stanford, CA, United States, 6Chemistry and Biochemistry, California State University, Fullerton, Fullerton, CA, United States

We describe the synthesis, development and in vivo application of sodium [1-13C]glycerate as a novel probe for evaluating glycolysis using hyperpolarized 13C MRS. [13C]glycerate displayed a high level of polarization and long spin-lattice relaxation time. In vivo spectroscopic studies with hyperpolarized [13C]glycerate in rat liver furnished metabolic products, pyruvate and lactate, originating from glycolysis. The levels of production and relative intensities of these metabolites were directly correlated with the induced glycolytic state (fasted versus fed). This work establishes hyperpolarized [13C]glycerate as a novel agent for clinically relevant 13C MRS studies of energy metabolism and further provides opportunities for evaluating intracellular redox states in biochemical investigations.

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