Abstract #0274

Hyperpolarized sodium [1-13C]glycerate as a probe for assessing glycolysis in vivo

Jae Mo Park^1,2,3, Marvin Wu⁴, Thomas Hever¹, Xiaodong Wen¹, Daniel M Spielman⁵, and Kelvin Billingsley⁶

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Electrical and Computer Engineering, University of Texas at Dallas, Richardson, TX, United States, ⁴Chemistry and Biochemistry, San Francisco State University, San Francisco, CA, United States, ⁵Stanford University, Stanford, CA, United States, ⁶Chemistry and Biochemistry, California State University, Fullerton, Fullerton, CA, United States

We describe the synthesis, development and in vivo application of sodium [1-¹³C]glycerate as a novel probe for evaluating glycolysis using hyperpolarized ¹³C MRS. [¹³C]glycerate displayed a high level of polarization and long spin-lattice relaxation time. In vivo spectroscopic studies with hyperpolarized [¹³C]glycerate in rat liver furnished metabolic products, pyruvate and lactate, originating from glycolysis. The levels of production and relative intensities of these metabolites were directly correlated with the induced glycolytic state (fasted versus fed). This work establishes hyperpolarized [¹³C]glycerate as a novel agent for clinically relevant ¹³C MRS studies of energy metabolism and further provides opportunities for evaluating intracellular redox states in biochemical investigations.

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