Abstract #0278

Hyperpolarized Carbon-13 Metabolic Imaging of Pediatric Patients with Brain Tumors: Initial Experience

Ilwoo Park¹, Adam Autry², Yiran Chen², Jeremy Gordon², Lucas Carvajal², Hsin-Yu Chen², Robert Bok², Mark Van Criekinge², James Slater², Cassie Kline-Nunnally³, Peder Larson², Daniel Vigneron², Janine Lupo², Duan Xu², and Sabine Mueller⁴

¹Radiology, Chonnam National University College of Medicine, Gwanju, Republic of Korea, ²Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ³Pediatric Hematology-Oncology, University of California San Francisco, San Francisco, CA, United States, ⁴Neurology, Neurosurgery and Pediatrics, University of California San Francisco, San Francisco, CA, United States

This study applied hyperpolarized ¹³C metabolic imaging in pediatric populations for the first time to our knowledge. Dynamic ¹³C data were acquired following injection of hyperpolarized [1-¹³C]pyruvate in the first 3 pediatric patients with brain tumors as part of an ongoing trial (PNOC011,NCT02947373). No adverse effects were observed for these 3 patients. Pyruvate, lactate and bicarbonate signals with high SNR were detected in the pediatric brain. These preliminary results demonstrated the feasibility of using HP [1-¹³C]pyruvate for assessing in vivo metabolism from pediatric patients with brain tumors and support ongoing investigation of this technology in pediatric patients.

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