Abstract #0277

Imaging the healthy human brain with hyperpolarized [1-13C] pyruvate

James T. Grist¹, Mary A. McLean², Surrin S. Deen¹, Frank Riemer¹, Charlotte J. Daniels¹, Andrew B. Gill¹, Fulvio Zaccagna¹, Rolf F. Schulte³, Sarah F. Hilborne¹, Jackie P. Mason¹, James W. McKay¹, Arnaud Comment⁴, Anita Chhabra⁵, Vicky Fernandes⁵, Hannah Loveday⁵, Marie-Christine Laurent¹, Ilse Patterson⁶, Ronnie Hernandez⁶, Rhys A. Slough⁶, Tomasz Matys¹, Ian B. Wilkinson⁷, Bristi Basu⁸, Claire Trumper⁹, Damian J. Tyler⁹, David J. Lomas¹, Martin J. Graves¹, Alasdair J. Coles¹⁰, Kevin Brindle², and Ferdia A. Gallagher¹

¹Radiology, University of Cambridge, Cambridge, United Kingdom, ²Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, ³Global Research, General Electric, Munich, Germany, ⁴Healthcare, General Electric, Cambridge, United Kingdom, ⁵Pharmacy, Addenbrooke's Hospital, Cambridge, United Kingdom, ⁶MRIS, Addenbrooke's Hospital, Cambridge, United Kingdom, ⁷Medicine, University of Cambridge, Cambridge, United Kingdom, ⁸Oncology, University of Cambridge, Cambridge, United Kingdom, ⁹Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, ¹⁰Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

Initial results from imaging the healthy human brain with [1-13C] pyruvate are presented. Labelled lactate and bicarbonate formation are seen, as well as differences in gray and white matter perfusion.

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