Abstract #0276

Hyperpolarized 13C Metabolic Imaging of Human Hypertrophic Cardiomyopathy

Angus Z. Lau^1,2, Albert P. Chen³, Justin Y.C. Lau^1,2, Benjamin J. Geraghty^1,2, William J. Perks⁴, Idan Roifman⁵, Graham A. Wright^1,2,5, Kim A. Connelly⁶, and Charles H. Cunningham^1,2

¹Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³GE Healthcare, Toronto, ON, Canada, ⁴Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁵Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁶Cardiology, St. Michael's Hospital, Toronto, ON, Canada

The feasibility of using hyperpolarized ¹³C to interrogate in vivo human metabolism in the healthy heart has recently been demonstrated. In this abstract we demonstrate the feasibility of using hyperpolarized ¹³C imaging to detect metabolic alterations in human hypertrophic cardiomyopathy. Results show significantly elevated¹³C-bicarbonate-to-pyruvate ratio near the apex of the heart, corresponding to the known location of disease. The ¹³C-bicarbonate images also show a different spatial distribution from those observed in healthy volunteers. These results show good prospects for imaging the altered cardiac energetics in the diseased heart using this technology.

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