Abstract #0282

Magnetic susceptibility of hemorrhagic myocardial infarction: correlation with tissue iron and comparison with relaxation time MRI

Brianna F. Moon¹, Srikant Kamesh Iyer PhD², Michael P. Solomon¹, Anya T. Hall¹, Rishabh Kumar³, Elizabeth M. Higbee-Dempsey⁴, Andrew Tsourkas PhD¹, Akito Imai MD⁵, Keitaro Okamoto MD⁵, Yoshiaki Saito MD⁵, Jerry Zsido II⁵, Joseph H. Gorman III MD⁵, Robert C. Gorman MD⁵, Giovanni Ferrari PhD⁶, and Walter R.T. Witschey PhD²

¹Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ²Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³Biophysics, University of Pennsylvania, Philadelphia, PA, United States, ⁴Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, United States, ⁵Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ⁶Surgery, Columbia University, New York City, NY, United States

Hemorrhagic myocardial infarction (MI) is a frequent complication of primary percutaneous coronary intervention and independently associated with impaired LV remodeling, function, and arrhythmias. We demonstrate that cardiac quantitative susceptibility mapping (QSM) shows increased susceptibility in infarcts compared to remote myocardium and correlates with iron content and infarct pathophysiology. QSM is a more specific marker of hemorrhagic MI than relaxation time MRI, susceptibility-weighted imaging, and late gadolinium enhanced (LGE) MRI.

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