Abstract #0289

The effects of cardiac allograft vasculopathy on intimal coronary artery wall thickness, myocardial fibrosis, and myocardial extracellular volume

Ruud B van Heeswijk^1,2, Jessica AM Bastiaansen¹, Juan F Iglesias³, Sophie Degrauwe³, Samuel Rotman⁴, Jérôme Yerly^1,2, Giulia Ginami^1,5, Matthias Stuber^1,2, and Roger Hullin³

¹Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ²Center for BioMedical Imaging (CIBM), Lausanne, Switzerland, ³Cardiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ⁴Pathology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ⁵School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

Cardiac allograft vasculopathy (CAV) occurs with a high prevalence after heart transplantation (HTx) and is a major cause of mid-term to late heart transplant failure. In this study we investigated whether the presence of CAV as diagnosed by x-ray coronary angiography or intima thickness as assessed by optical coherence tomography (OCT) is linked with the myocardial T1 relaxation time, extracellular volume, or interstitial fibrosis as assessed by endomyocardial biopsies (EMB).

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