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Abstract #0290

The Difference between Extracellular Space Expansion and Diffuse Myocardia Fibrosis in Defferent Severity Distolic Dysfunction (DD) Type 2 Diabetes Mellitus (T2DM) Rhesus Monkeys using Excellelar Volume mapping and Non-contrast T1ρ mapping

Yu Zhang1, Li Gong2, Yushu Chen1, Wen Zeng2, Jie Zheng3, and Fabao Gao1,2

1West China Hospital, Sichuan University, Chengdu, China, 2Sichuan Primed Bio-Tech Group Co., Ltd, Chengdu, China, 3Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States

In this study, diffuse myocardial fibrosis was quantifitied in type 2 diabetes mellitus (T2DM) rhesus monkeys with different severity diastolic dysfunction (DD) using ECV derived from T1 mapping and mFI derived from non-contrast T1ρ mapping. Different behaviors of ECV and mFI to differentiate HC from T2DM with mild DD was observed. This reflects the difference between extracellular space expansion and collagen content during the process of myocardial fibrosis. This difference is benifite for us to better understand the pathophysiology of DD.

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