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Abstract #0303

Non-contrast assessment of blood-brain-barrier permeability with water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) MRI

Zixuan Lin1, Yang Li1, Pan Su1, Deng Mao1, Zhiliang Wei1, Jay Pillai1, Abhay Moghekar2, Matthias van Osch3, Yulin Ge4, and Hanzhang Lu1

1Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Department of Neurology, Johns Hopkins University, Baltimore, MD, United States, 3Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 4Department of Radiology, New York University Langone Medical Center, New York, NY, United States

A new method for non-contrast assessment of blood-brain-barrier (BBB) permeability to water has been proposed: water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) MRI, which allows selective imaging of venous ASL signal. Studies were performed to show proof-of-principle and Look-Locker readout were applied to expedite data acquisition. The results were consistent with previous literature. Mild hypercapnia was also shown to enhance the sensitivity of the technique significantly.

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