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Abstract #0304

Investigation into water transport mechanisms in the brain using a combination of T2 measurements and crusher gradients with ASL

Leonie Petitclerc1, Sophie Schmid1,2, Wouter M. Teeuwisse1,2, and Matthias J. P. van Osch1,2

1C.J. Gorter Center for High Field MRI, Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden Institute of Brain and Cognition, Leiden, Netherlands

TRUST and crusher gradients were combined with time-encoded pCASL to examine the transport of water from the vasculature to the tissue in the brain. At early time points, where the intravascular portion of the ASL signal is high, the crusher gradients resulted in a large reduction in the average signal. By comparing the intravascular fraction obtained from crushed signal to T2 measurements, it was observed that the change in T2 is greater in later time points than the change in intravascular fraction. This suggests that T2 methods are more sensitive to alterations in the blood-brain barrier than crusher gradient techniques.

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