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Abstract #0307

Cerebral Blood Volume Mapping using Fourier-Transform based Velocity-Selective Saturation Pulse Trains

Qin Qin1,2, Yaoming Qu3, Wenbo Li1,2, Dapeng Liu1,2, Taehoon Shin4,5, Doris Lin1, Peter van Zijl1,2, and Zhibo Wen3

1Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China, 4Ewha Womans University, Seoul, Republic of Korea, 5Case Western Reserve University, Cleveland, OH, United States

A new non-contrast cerebral blood volume (CBV) quantification technique is proposed using Fourier-transform based velocity-selective saturation (FT-VSS) pulse trains. Its utility is assessed for healthy subjects at 3T and compared to a method using conventional flow-dephasing VS pulse trains. FT-VSS showed greater immunity to gradient imperfections and up to 40% higher SNR. The better performance of FT-VSS pulse trains in CBV measurements can be explained by the effective background suppression related to its velocity-selective profile: static tissue signal in the saturation band and flowing spins in the passband, which is opposite from the velocity response of the conventional method.

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