Abstract #0308

Robust estimation of quantitative perfusion from multi-phase pseudo-continuous arterial spin labelling

Michael A Chappell¹, Martin Craig¹, James R Larkin², Manon A Simard², Nicola R Sibson², and Thomas W Okell³

¹Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ²Cancer Research UK & Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, ³Wellcome Centre for Integrative Neuroimaging, FMRIB, University Oxford, Oxford, United Kingdom

Multi-phase pcASL has been proposed as a means to achieve accurate perfusion quantification that is robust to imperfect shim in the labelling plane. There exists a previously unrecognised bias in the estimation process that is a function of noise on the data. In this work this boas is addressed, exploiting information common to voxels containing tissue fed by the same artery, identified using clustering methods.

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