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Abstract #0320

Accelerated quantitative susceptibility and R2* mapping with flexible k-t-segmented 3D-EPI

Rüdiger Stirnberg1, Andreas Deistung2,3,4, Jürgen Reichenbach2, and Tony Stöcker1,5

1MR Physics, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 2Medical Physics Group, Institute of Diagnostic and Interventional Radiology, University Hospital Jena, Jena, Germany, 3Department of Neurology, Essen University Hospital, Essen, Germany, 4Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany, 5Department of Physics and Astronomy, University of Bonn, Bonn, Germany

We introduce and demonstrate a novel “k-t-segmented” gradient echo 3D-EPI variant for motion-robust, rapid quantitative susceptibility and R2* mapping at 3T. The combination of a versatile 2D-CAIPIRINHA EPI sampling (“k-segmentation”) and two complementing multi-echo options (“t-segmentation”) provides maximum time- and SNR-efficiency by acquiring exactly as many k-space lines per echo time as fit to the required R2* sampling without compromising spatial resolution. Offline averaging of multiple, rapid measurements (here: 6 averages, 6 echo times from 6.5-31.5ms, 52s/average) following optional, retrospective correction for motion and B0 drift, yields excellent quantitative whole-brain maps at 0.8mm isotropic resolution acquired in approximately 5 minutes.

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