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Abstract #0321

Myelin Lipid 1H Density Measurements by IR-UTE are Consistent Before and After D2O Exchange

Alan C Seifert1,2, Michael J Wilhelm3, Suzanne L Wehrli4, and Felix W Wehrli1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Chemistry, Temple University, Philadelphia, PA, United States, 4SAIF Core Facility, Children's Hospital of Philadelphia, Philadelphia, PA, United States

In this work, the efficacy of long-T2 tissue water suppression by adiabatic inversion-recovery preparation is examined by IR-UTE imaging of an ovine spinal cord specimen in native hydration and deuterium oxide (D2O)-exchanged states. Myelin density in three white matter regions of interest (ROIs) was found to be 18.1% to 23.5% in the non-exchanged cord, and 19.9% to 22.5% in the D2O-exchanged cord, with the highest density in the dorsal columns. The agreement of myelin density measurements between non-exchanged and D2O-exchanged cords supports the efficacy of tissue water suppression in white matter by adiabatic inversion-recovery with an appropriately-chosen TI.

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