Diffusion tensor imaging of the hippocampus in temporal lobe epilepsy (TLE) has previously relied on very low spatial resolution acquisitions, limiting localization of hippocampal substructure and leading to partial volume effects in diffusion parameter quantification. This study uses a high resolution (1x1x1 mm3) single-shot diffusion protocol to yield excellent quality mean diffusion weighted images (DWIs) that allow for visualization of hippocampal substructure (e.g. presence/absence of the stratum lacunosum moleculare). Improved delineation of structure allows for segmentation of the hippocampus in native space (without co-registration to anatomical images), revealing elevated MD and loss of internal architecture in TLE subgroups.
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