Abstract #0339

Voxel-wise ratios of amide proton transfer (APT) signals and standardized uptake values (SUVs) of fluorodeoxyglucose (FDG) in the differentiation of myxoid-rich soft-tissue tumors with FDG-PET/MR imaging

Koji Sagiyama¹, Yuji Watanabe², Keisuke Ishimatsu¹, Takeshi Kamitani¹, Yuzo Yamasaki², Takuya Hino¹, Sungtak Hong³, Jochen Keupp⁴, Yoshihiro Matsumoto⁵, and Hiroshi Honda¹

¹Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ³Healthcare, Philips Electronics Japan, Tokyo, Japan, ⁴Philips Research, Hamburg, Germany, ⁵Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

It is often difficult to differentiate myxoid-rich soft-tissue tumors on conventional imaging. In this study, we performed a direct voxel-wise comparison of amide proton transfer (APT) signals and standardized uptake values (SUVs) obtained on FDG-PET/MR imaging. Among myxoid-rich tumors including myxoid liposarcomas, myxofibrosarcomas, myxoid chondrosarcomas, and schwannomas, the mean APT/SUV was significantly higher in liposarcomas than in the other myxoid-rich tumors while a single parameter such as APT, SUV or apparent diffusion coefficient (ADC) did not show any significant differences between the two groups. The APT/SUV could be a reliable bio-imaging marker for differentiating soft-tissue tumors.

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