Abstract #0340

Assessment of early treatment response by multiparametric whole-body MRI as a 1-step approach to prediction of overall response rate in patients with multiple myeloma

Miyuki Takasu¹, Takayuki Tamura¹, Yuji Akiyama¹, Yoko Kaichi¹, Shota Kondo¹, Chihiro Tani¹, and Kazuo Awai¹

¹Department of Diagnostic Radiology, Hiroshima University Hospital, Hiroshima, Japan

We compared remission status at completion of chemotherapy with changes in MRI biomarkers obtained by advanced MRI techniques, including total tumor volume calculated from whole-body diffusion-weighted imaging and fat fraction by mDIXON soon after induction of chemotherapy for patients with multiple myeloma. The early change in fat fraction of lumbar bone marrow and serum monoclonal protein after 2 cycles of chemotherapy contributed significantly to the prediction of CR/VGPR status. Results of this study may indicate that prediction of remission status can be achieved by assessing bone marrow on lumbar spinal MRI with mDIXON.

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