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Abstract #0363

Non-invasive pressure-volume loops from cardiovascular magnetic resonance and brachial pressure

Felicia Seemann1,2, Per Arvidsson1, David Nordlund1, Sascha Kopic1, Marcus Carlsson1, Håkan Arheden1, and Einar Heiberg1,2

1Department of Clinical Physiology, Skåne University Hospital, Lund University, Lund, Sweden, 2Department of Biomedical Engineering, Faculty of Engineering, Lund University, Lund, Sweden

Cardiac pressure-volume loop analysis provides important information on cardiac function, but is currently not widely utilized clinically since invasive measurements are required. This study aimed to develop and validate a non-invasive method of estimating pressure-volume loops, via a model-based framework using cardiovascular magnetic resonance. The method yields individualized pressure-volume loops computed using time-varying elastance, with left ventricular volume and brachial pressure as input. Experimental validation showed strong agreement to in-vivo measurements, and application to healthy controls and heart failure patients yielded expected results. Hence, the model is a promising method for obtaining pressure-volume loops from magnetic resonance imaging.

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