Abstract #0364

Subtle changes in hyperelastic properties of myocardium with cardiotoxicity remodeling from CMR

Delphine Perie-Curnier¹, Marianna Gamba¹, Marilou Trempe¹, Jenny Wang², Martyn Nash², Alistair Young³, and Daniel Curnier⁴

¹Mechanical Engineering, Polytechnique Montreal, Montreal, QC, Canada, ²Biomedical Engineering, University of Auckland, Auckland, New Zealand, ³Anatomy with Radiology, University of Auckland, Auckland, New Zealand, ⁴Kinesiology, University of Montreal, Montreal, QC, Canada

The aim of this study was to assess subtle changes in 3D geometrical and mechanical properties of left ventricle in childhood acute lymphoblastic leukemia survivors. Global 3D volume or ejection fraction were not sensitive enough while time dependent 3D geometrical parameters over the cardiac cycle showed that early diastole is more affected than systole or late diastole. Smaller hyper-elastic properties were found in the high risk group than in the standard risk, high risk with cardioprotective agent or healthy volunteers group. High temporal resolution and local parameters would improve the detection of these subtle changes.

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