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Abstract #0372

Sensitivity and specificity of cerebrovascular reactivity in predicting surgical decisions in Moyamoya patients

Peiying Liu1, Babu G Welch2, Binu P Thomas2, Yang Li1, Marco C Pinho2, Judy Huang1, and Hanzhang Lu1

1Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2University of Texas Southwestern Medical Center, Dallas, TX, United States

Moyamoya disease (MMD) is characterized by chronic occlusion of the distal intracranial internal carotid arteries and can be treated by revascularization surgery. At present, surgical decisions are primarily based on symptomatology and imaging studies such as DSA and SPECT. However, current procedures are costly, invasive, and qualitative. Here we applied a novel iVas-MRI technique that provides quantitative assessment of multiple hemodynamic parameters in a single scan of 9 minutes, and examined its sensitivity and specificity in predicting surgical decisions. Our results showed that iVas-MRI has an overall accuracy of 0.93 in predicting surgical decisions in MMD.

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