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Abstract #0373

Baseline Risk Factors Suggestive of Advanced Vascular Disease Predict Differences in Brain CBF Changes After Carotid Revascularization Surgery

Salil Soman1, Kyuwon Lee2, Weiying Dai3, Elizabeth Hitchner4, Michael Moseley4, Greg Zaharchuk4, Allyson Rosen4, and Wei Zhou5

1HMS / BIDMC, Boston, MA, United States, 2TUFTS Medical School, Boston, MA, United States, 3SUNY Binghamton, Binghamton, NY, United States, 4Stanford School of Medicine, Stanford, CA, United States, 5University of Arizona, Tucson, AZ, United States

Carotid stenosis is a risk factor for stroke. A number of risk factors are associated with stroke. Our work shows specific risk factors that predict differences in brain perfusion using ASL MRI technique after carotid revascularization surgery. Specifically elevated systolic blood pressure, chronic renal insufficiency, and history of prior stroke have mpacts on initial baseline to immediately post surgery prefusion increase, and baseline elevated cholesterol and body mass index show differences in 1 day to 6 months post operation. This is in contrast to hypertension, smoking and diabetes, which did not show significant predict relationships. Our work suggests that these risk factors may be more closely related to cerebrovascular dysfunction.

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