Fast imaging with ultrahigh isotropic resolution has gained widespread interests but is technically challenging. The simultaneous multi-slice (SMS) and 3D imaging can hardly achieve high isotropic resolution without compromising temporal resolution or imaging contrast that needs long TR. A novel method, Partition-encoded Simultaneous Multi-slab (PRISM) imaging, was proposed to mitigate the physical constraints of thin slice excitation by applying partition encoding onto simultaneous multi-slab acquisition and provide ultrahigh isotropic resolution while maintaining the acceleration capability and TR flexibility. Using the PRISM technique, whole-brain fMRI with spatial resolution of 1mm isotropic and a temporal resolution of 2 seconds has been achieved.
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