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Abstract #0384

Synthetic MP2RAGE: multiple ‘on-demand’ contrasts from a single acquisition

Aurélien Massire1,2, Thomas Troalen3, Olivier M Girard1,2, Tobias Kober4,5,6, Bénédicte Maréchal4,5,6, Maxime Guye1,2, Jean-Philippe Ranjeva1,2, and Virginie Callot1,2

1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3Siemens Healthcare SAS, Saint-Denis, France, 4Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 5Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, 6Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

MP2RAGE and FLAWS sequences are increasingly used for brain clinical research imaging at ultra-high field. Yet, the ability to provide at the same time an optimal contrast between GM and WM for segmentation, an accurate T1 mapping and/or the ability to highlight only a single tissue or lesions, is in practice not possible with only one single MP2RAGE acquisition. In this work, we demonstrate that synthetic ‘uniform’ images with ‘on-demand’ clinically relevant contrasts could be generated at 7T from a single MP2RAGE acquisition providing an accurate T1 map, allowing for instance tissue signal nulling or lesion signal enhancement.

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