MP2RAGE and FLAWS sequences are increasingly used for brain clinical research imaging at ultra-high field. Yet, the ability to provide at the same time an optimal contrast between GM and WM for segmentation, an accurate T1 mapping and/or the ability to highlight only a single tissue or lesions, is in practice not possible with only one single MP2RAGE acquisition. In this work, we demonstrate that synthetic ‘uniform’ images with ‘on-demand’ clinically relevant contrasts could be generated at 7T from a single MP2RAGE acquisition providing an accurate T1 map, allowing for instance tissue signal nulling or lesion signal enhancement.
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