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Abstract #0385

Interleaved SPEN with per-shot correction for high definition human DTI measurements

Samuel F. Cousin1, Gilad Liberman1, Eddy Solomon1, and Lucio Frydman1

1Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel

Sub-mm DTI is of great interest for clinical diagnosis and healthy tissue studies. Segmented imaging is hindered in these applications, due to complications associated to unavoidable motions in-between shots. This work demonstrates the advantages resulting from using interleaved, segmented SPatially ENcoded (SPEN) methods for DTI, thanks to their ability to (i) provide low-resolution but fully sampled images per shot; (ii) compensate for rigid-body motions by simple phase corrections, and (iii) zoom on restricted FOVs without folding complications. All this enables high-resolution diffusion MRI on humans, as shown here by delineating the pons anatomy at a 0.74mm in-plane resolution.

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