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Abstract #0395

The EPI rs-fMRI signal shows an orientation effect with respect to B0 and phase-encode axis across cortical depth

Olivia M Viessmann1, Marta Bianciardi1, Klaus Scheffler2, Lawrence L Wald1,3, and Jonathan R Polimeni1,3

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States, 2Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 3Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

The cortex exhibits a strict vascular architecture and vessel orientation to the B0 field should impact the local susceptibility and hence the local BOLD signal. Cortical folding could thus lead to local variations in the signal. Here, we used high-resolution 7T EPI rs-fMRI data and found substantial variations of the signal amplitdude's coefficient of variation (σ/μ) with the local cortical orientation to B0. This effect was measurable throughout cortical depths with a maximised effect of +70% at the surface. We compare this to orientation-dependent blurring effects along the phase-encode axis, which we found to be significant too.

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