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Abstract #0394

True laminar resolution fMRI of the human visual cortex at 7T

Sriranga Kashyap1,2, Dimo Ivanov1,2, Shubharthi Sengupta1,2, Benedikt A. Poser1,2, and Kâmil Uludağ1,2

1Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, 2Maastricht Brain Imaging Centre (MBIC), Maastricht, Netherlands

Current laminar BOLD fMRI studies at ultra-high field are typically carried out at sub-millimetre spatial resolution (~0.7mm isotropic), which, however, results in each voxel covering more than one cortical layer. Thus, layer-resolved activation profile can only be obtained if such data is analysed with post-processing tools at super-resolution. In this study, we demonstrate a novel functional mapping approach by acquiring fMRI data at true laminar resolution (100µm) in humans at 7T, compare it to the conventional high-resolution GE-EPI and analyse the depth-dependent BOLD signal change to visual stimulation.

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