Meeting Banner
Abstract #0405

Europium(2+/3+) dual mode MRI contrast agents: combining paraCEST and T1w contrast in one oxygen-sensitive agent.

Alexander Max Funk1, Veronica Clavijo-Jordan1, Dean Sherry1,2, James Ratnakar1, and Zoltan Kovacs1

1UT Southwestern Medical Center, Dallas, TX, United States, 2University of Texas at Dallas, Dallas, TX, United States

The ability to determine hypoxia in tumors in vivo could provide useful diagnostic contrast information. MRI contrast agents could provide this information. Eu2+ is isoelectronic with Gd3+, and produces T1w contrast on a similar level, in addition, it is not oxidatively stable. In an aerobic atmosphere, it oxidizes rapidly to Eu3+, which does not produce T1 contrast, but can belong to a conceptually different class of contrast agents: paraCEST (chemical exchange saturation transfer) agents. A Eu2+/3+ agent was tested in different tissues in-vivo to show the correlation between the rate of oxidation and the surrounding oxidative environment of the tissue.

This abstract and the presentation materials are available to members only; a login is required.

Join Here