Developing new tools that can be used to detect changes in renal tissue is of great interest for nephrologists. Indeed, standard measurements of blood-urea nitrogen and serum creatinine might not detect kidney injury until a 50% loss in function occurs. As kidneys play a preeminent role in controlling acid-base balance, pH mapping should enable early detection of changes in renal health. Here we propose administration of salicylate based diaCEST MRI agents to map renal pH. As we show, aspirin and three analogs: salicylic acid, 2,4-dihydroxy benzoic acid, 2,5-dihydroxy benzoic acid displayed promise in vitro and in vivo for pH mapping.
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