Meeting Banner
Abstract #0407

Development and Proof of Principle for Free Radical Imaging with the Novel Field-cycling in vivo DNP-MRI

Hideo Utsumi1,2, Toshiki Masumizu1,2, Ryoma Kobayashi1,3, Utaroh Motosugi4, Tatsuya Shimizu4, Tomoko Tahira1,5, Atsushi Iikura6, and Hidenori Kajiwara6

1Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, Japan, 2Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan, 3Osaka University, Suita, Japan, 4University of Yamanashi, Yamanashi, Japan, 5Kinjo Gakuin University, Nagoya, Japan, 6Fuji Electric Co., Ltd, Tokyo, Japan

In vivo DNP-MRI was reported as a new imaging method for free radical species in vivo1, and the field-cycling was utilized to overcome the large difference between electron and nuclear spin resonances2,3. Unfortunately the development of the clinical DNP-MRI has severe difficulties due to less applicability.

Here, we developed the novel field-cycling DNP-MRI for clinical trial by rotating the magnets for MRI (0.3T) and ESR (4.7mT), and the free radicals placed under the palm of volunteers were visualized, superimposed on the anatomical MRI image, and demonstrated the proof of principle for free radical imaging with the newly developed field-cycling DNP-MRI.

This abstract and the presentation materials are available to members only; a login is required.

Join Here