Abstract #0407

Development and Proof of Principle for Free Radical Imaging with the Novel Field-cycling in vivo DNP-MRI

Hideo Utsumi^1,2, Toshiki Masumizu^1,2, Ryoma Kobayashi^1,3, Utaroh Motosugi⁴, Tatsuya Shimizu⁴, Tomoko Tahira^1,5, Atsushi Iikura⁶, and Hidenori Kajiwara⁶

¹Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, Japan, ²Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan, ³Osaka University, Suita, Japan, ⁴University of Yamanashi, Yamanashi, Japan, ⁵Kinjo Gakuin University, Nagoya, Japan, ⁶Fuji Electric Co., Ltd, Tokyo, Japan

In vivo DNP-MRI was reported as a new imaging method for free radical species in vivo¹, and the field-cycling was utilized to overcome the large difference between electron and nuclear spin resonances^2,3. Unfortunately the development of the clinical DNP-MRI has severe difficulties due to less applicability.

Here, we developed the novel field-cycling DNP-MRI for clinical trial by rotating the magnets for MRI (0.3T) and ESR (4.7mT), and the free radicals placed under the palm of volunteers were visualized, superimposed on the anatomical MRI image, and demonstrated the proof of principle for free radical imaging with the newly developed field-cycling DNP-MRI.

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