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Abstract #0410

Decoding IDH Genotype in Grade-II and -III Gliomas with Protein-based Amide Proton Transfer-Weighted (APTw) MRI

Shanshan Jiang1,2, Qihong Rui1, Hao Yu1, Yu Wang3, Yi Zhang4, Hye-Young Heo2, Jinyuan Zhou2, and Zhibo Wen1

1Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China, 2Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 3Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou, China, 4Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China

We explored the possibility of using the APTw signal intensity as a surrogate marker to identify IDH mutation status in gliomas. 105 patients with newly diagnosed grade-II/III gliomas were included. APTw histogram data obtained from tumor burden was recorded. The Mean, Peak, 10th, 25th, 50th, 75th, 90th Percentiles of APTw signal histograms were significantly higher in the IDH-wildtype group than in the IDH-mutant group. The classification for 50th Percentile APTw to differentiate these two glioma groups was 78.1%. Preoperative APTW imaging may assist in predicting the IDH mutation status in gliomas.

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