Abstract #0410

Decoding IDH Genotype in Grade-II and -III Gliomas with Protein-based Amide Proton Transfer-Weighted (APTw) MRI

Shanshan Jiang^1,2, Qihong Rui¹, Hao Yu¹, Yu Wang³, Yi Zhang⁴, Hye-Young Heo², Jinyuan Zhou², and Zhibo Wen¹

¹Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China, ²Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ³Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou, China, ⁴Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China

We explored the possibility of using the APTw signal intensity as a surrogate marker to identify IDH mutation status in gliomas. 105 patients with newly diagnosed grade-II/III gliomas were included. APTw histogram data obtained from tumor burden was recorded. The Mean, Peak, 10^th, 25^th, 50^th, 75^th, 90^th Percentiles of APTw signal histograms were significantly higher in the IDH-wildtype group than in the IDH-mutant group. The classification for 50^th Percentile APTw to differentiate these two glioma groups was 78.1%. Preoperative APTW imaging may assist in predicting the IDH mutation status in gliomas.

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