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Abstract #0411

Quantifying the glucose CEST Effect in Patients with oropharyngeal squamous cell carcinoma at 3T in vivo using an oxygen challenge

Alex K. Smith1, Tessa Greenhalgh2, Nia Taylor3, Benjamin Irving4, Ketan Shah3, Daniel Bulte4, Martin Craig4, Michael Chappell4, Fergus Gleeson2, and Brian Burns2,5

1Wellcome Centre for Integrative Neuroimaging, FMRIB, University of Oxford, Oxford, United Kingdom, 2Department of Oncology, University of Oxford, Oxford, United Kingdom, 3Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, United Kingdom, 4Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom, 5MR Applied Sciences Lab, GE Healthcare, Menlo Park, CA, United States

Characterizing tumor treatment response is an ongoing radiological challenge as both the anatomical and physiological characteristics of the tumor are changing as the treatment course progresses. GlucoCEST imaging may provide an avenue towards understanding the evolving tumor metabolic environment over the course of treatment. In this preliminary assessment, we show that an oxygen challenge can highlight changes in the vasculature of tumors post radiotherapy.

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