Abstract #0411

Quantifying the glucose CEST Effect in Patients with oropharyngeal squamous cell carcinoma at 3T in vivo using an oxygen challenge

Alex K. Smith¹, Tessa Greenhalgh², Nia Taylor³, Benjamin Irving⁴, Ketan Shah³, Daniel Bulte⁴, Martin Craig⁴, Michael Chappell⁴, Fergus Gleeson², and Brian Burns^2,5

¹Wellcome Centre for Integrative Neuroimaging, FMRIB, University of Oxford, Oxford, United Kingdom, ²Department of Oncology, University of Oxford, Oxford, United Kingdom, ³Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, United Kingdom, ⁴Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom, ⁵MR Applied Sciences Lab, GE Healthcare, Menlo Park, CA, United States

Characterizing tumor treatment response is an ongoing radiological challenge as both the anatomical and physiological characteristics of the tumor are changing as the treatment course progresses. GlucoCEST imaging may provide an avenue towards understanding the evolving tumor metabolic environment over the course of treatment. In this preliminary assessment, we show that an oxygen challenge can highlight changes in the vasculature of tumors post radiotherapy.

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