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Abstract #0422

Resting state functional corticostriatal connectivity in Parkinsonian monkeys

Joonas A Autio1, Takayuki Ose1, Kantaro Nishigori1, Noboyoshi Tanki1,2, Jun Takahashi3, Matthew F Glasser4,5, and Takuya Hayashi1

1Center for Life Science Technologies, RIKEN, Kobe, Japan, 2Okayama University, Okayama, Japan, 3Kyoto University, Kyoto, Japan, 4Department of Neuroscience, Washington University, St. Louis, MO, United States, 5St. Luke's hospital, St. Louis, MO, United States

Studies in animal models of Parkinson’s disease have established that excessive synchronization of neuronal activity in basal ganglia cortical loops is the hallmark of movement disorders in Parkinson’s disease. However, majority of the studies have focused on basal ganglia and motor areas in Parkinson’s disease models and it is still unclear how dopamine denervation influences other neocortical areas, which each exhibit distinct corticostriatal and thalamocortical connectivity profiles. To address this issue, we investigate the effects of dopaminergic neuronal loss on functional connectome using resting-state fMRI in anesthetized MPTP-treated monkeys.

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