Abstract #0423

MR imaging of neuromelanin-iron cluster within human postmortem substantia nigra

Hansol Lee¹, Sun-Yong Baek², Se Young Chun³, Jae-Hyeok Lee⁴, and HyungJoon Cho¹

¹Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea, ²Department of Anatomy, Pusan National University School of Medicine, Yangsan, Republic of Korea, ³Department of Electrical and Computer Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea, ⁴Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea

The overall goal of this work was to provide a truth of neuromelanin-sensitive T₁ weighted image with magnetization transfer effects and to segment the respective distribution of neuromelanin-iron complex and ferric iron within substantia nigra which are important to monitor Parkinson’s disease. Postmortem MR experiment at 7T and histological validation were performed for six normal midbrain samples. The correlation between T₂*/T₂ and neuromelanin pigments was highest compared to other MR parameters, especially compared to T₂*, which shows specific distributions of paramagnetic molecules. Iron deposits were highly correlated with iron-sensitive T₂ and T₂* and the correlation was reduced for T₂*/T₂.

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