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Abstract #0426

Disrupted Cortical and Subcortical Effective Connectivity in Early Parkinson’s Disease (PD): Insights from Parkinson’s Progressive Markers Initiative (PPMI) dataset

Karthik R Sreenivasan1, Ece Bayram1, Virendra Mishra1, Zhengshi Yang1, Christopher Bird1, Xiaowei Zhuang1, Dietmar Cordes1,2, and Brent Bluett1

1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Colorado Boulder, Boulder, CO, United States

This study utilized resting-state fMRI data to evaluate effective (directional) connectivity in newly diagnosed unmedicated patients with early PD to derive a comprehensive picture of the nature of cortico–striatal–thalamic loop connectivity in PD. We found decreased effective connectivity between the key areas in the cortico–striatal–thalamic loops in unmedicated early stage PD patients . These results were mostly lateralized to the hemisphere opposite the predominant side of parkinsonian symtoms. The findings of this study are mainly important, given the fact that, looking at changes in effective connectivity and its relation to different disease related factors may help us better understand the heterogeneity of PD and more accurately target therapeutic interventions (i.e. deep brain stimulation).

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