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Abstract #0427

Role of hippocampus in genesis of visual hallucinations in Parkinson’s disease: Insights from hippocampal sub-volumetry analysis

Abhishek Lenka1, Apurva Shah2, Jitender Saini3, Madhura Ingalhalikar4, and Pramod Kumar Pal1

1Neurology, NIMHANS, Bengaluru, India, 2Symbiosis International University, Pune, India, 3NIMHANS, Bengaluru, India, 4Department of Electronics, Symbiosis Institute of Technology, Symbiosis International University, Pune, India

The neurobiological underpinnings of psychosis, manifested through visual hallucinations (VH) in Parkinson’s disease (PD), are not fully elucidated, however, are linked to memory impairment and are associated with alterations in the hippocampus. To obtain profound understanding of the role of hippocampus in VH, a hippocampal subfield volumetric analysis on PD patients with (PD-P) and without psychosis (PD-NP) and healthy controls (HC) was performed. The results demonstrated a clear pattern with lowest volumes in PD-P, followed by PD-NP and the highest in HCs in several subfields. Moreover, the PD-P volumes in multiple sub-fields highly correlated with memory and attention scores.

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