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Abstract #0444

Standardisation and quantification of 23Na-MRI: repeatability and reproducibility of sodium imaging

Damien J McHugh1,2, Frank Riemer2,3, Daniel Lewis1, Fulvio Zaccagna2,3, Ferdia A Gallagher2,3, and Geoffrey J. M. Parker1,2,4

1Informatics, Imaging and Data Sciences, The University of Manchester, Manchester, United Kingdom, 2CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester, United Kingdom, 3Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 4Bioxydyn Ltd., Manchester, United Kingdom

Based on its sensitivity to cell viability and tissue microstructure, sodium MRI has the potential to provide quantitative biomarkers of tumor grade and response to therapy. For biomarkers such as total sodium concentration (TSC) to have clinical utility, they require technical and biological validation. This work focuses on the technical validation of TSC, specifically assessing the repeatability and reproducibility of measurements in healthy volunteers. The results presented here show consistent TSC measurements across repeated scans at different sites, and good repeatability and reproducibility (coefficients of variation, CoVs < 10%).

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