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Abstract #0445

Improved Quantification of Hepatic Fatty Acid Metabolism in Nonalcoholic Steatohepatitis: Serum Biochemistry and In vivo Proton MRS Study with Spin-Spin Relaxation Time Correction at 9.4 T

Kyu-Ho Song1, Min-Young Lee1, Song-I Lim1, Chi-Hyeon Yoo1, and Bo-Young Choe1

1Department of Biomedical Engineering and Research Institute of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

Changes in saturated and unsaturated fatty acids with hepatic triglycerides following the formation of abnormal metabolites, which play an important pathogenic role, can be measured by magnetic resonance (MR) spectroscopy. High-field-strength MR imaging scanners, which have an improved signal-to-noise ratio and high resolution for multiple lipid resonance components, are used to detect each component of lipid resonance. The aims of this study were to quantify hepatic lipid content and triglyceride composition in a preclinical nonalcoholic steatohepatitis model during the progression of steatohepatitis by assessing potential biomarkers, including spin-spin relaxation time, and applying in vivo proton MR spectroscopy with serum biochemistry.

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